Tag Archives: weight gain

Weight Loss Surgery Benefits May Diminish Over Time

Weight-loss surgeries for obesity are very popular, often producing dramatic fat loss and reducing type-2 diabetes, according a new study. The problem is that patients regain weight and health problems return in the long run.

Laparoscopic Sleeve Gastrectomy

Weight loss surgery benefits for obesity fade over time, according to new study. Photo by Daryl S. Marx M.D.

Diet and exercise are essential for any long term weight loss from my experience but I understand this is very difficult for anyone who is already obese.

A new study published in JAMA Surgery reviewed patients’ files between one and five years who underwent laparoscopic sleeve gastrectomy (LSG). It discovered that patients who had that kind of surgery encountered significant weight gain and a return of type 2 diabetes years later.

A sleeve gastrectomy is basically the removal of part of the stomach and creating a long, slim sleeve, or pouch, from the remaining section of the stomach, according to the U.S. National Institute of Diabetes and Digestive and Kidney Disease (NIDDK). When the size of the stomach is reduced it limits the amount of food you can consume. Also, it suppresses appetite, lowers blood sugar and changes gut hormones.

“Weight-loss surgery is not a panacea for weight loss over the long run,” said lead researcher Dr. Andrei Keidar, of the Beilinson Hospital in Petah Tikva, Israel.

Keidar says the main reason for weight regain is that the stomach dilates, which means you can eat more. The appetite returns so individuals can consume more and they desire to eat more (JAMA Surg.).

Data was collected on nearly 450 patients between April 2006 and February 2013. However, only 39 patients had a full follow-up by the fifth year after surgery. It seems patients either were ashamed or just became discouraged and did not want to report which could have ended in a biased study.

Patients lost 77 percent of their excess weight in the first year of surgery. Shockingly, they regained weight by the fifth year, resulting in only a 56 percent fat loss. Also, 51 percent of people eliminated type 2 diabetes in the first year. In the fifth year, only 20 percent were still clear of the disease, said researchers (JAMA Surg.).

I agree with Keidar that weight loss surgery is a “behavioral surgery”. If you do not switch up your lifestyle you will regain weight.

Even though patients may regain weight and develop diabetes again, I still believe weight-loss surgery is the best option for obese patients.

Leeman Taylor
Bachelor Degree in Criminal Justice
Real Estate Investor & Internet Marketer

Source: Golomb I, Ben David M, Glass A, Kolitz T, Keidar A. “Long-term Metabolic Effects of Laparoscopic Sleeve Gastrectomy” JAMA Surg. Published online August 05, 2015. doi:10.1001/jamasurg.2015.2202.

New Weight Loss Diet Pill Acts As “Imaginary Meal”

Obese individuals seeking to lose weight have many FDA-approved prescription drugs to choose from including Belviq and newly approved Saxenda. There is still a long journey for better weight loss as scientists develop new fat loss alternatives every day.

Diet Pill Fexaramine - Ronald Evans

Evans and his colleagues develop Fexaramine, a compound that tricks the brain into feeling full, causing your body to burn fat. Salk Institute photo

Researchers at Salk Institute recently developed fexaramine; a pill that tricks the body into thinking it has consumed calories, causing it to burn fat. This new weight loss pill effectively stopped weight gain, controlled blood sugar, lowered cholesterol and decreased inflammation in mice, making it a great candidate for fast transition into human clinical studies (Evans et al. 2015). Many of the prescription drugs that we have currently on the market like caffeine-based drugs or appetite suppressants dissolve in the blood, but fexaramine stays in the intestines causing lesser side effects.

There was a study published earlier this month on how diet pills or weight loss supplements rarely work without diet or exercise but this new pill could really be an effective option for obesity. “This pill is like an imaginary meal” says Ronald Evans, director of Salk’s Gene Expression Laboratory and senior author of the new paper, published January 5, 2014 in Nature Medicine. “It sends out the same signs that normally happen when you eat a lot of food, so the body starts clearing out space to store it. But there are no calories and no change in appetite.”

Evans and his colleagues gave obese mice a daily pill of fexaramine for 5 weeks in which the mice stopped gaining weight, lost fat and had lower cholesterol and blood sugar levels than untreated mice (Evans et al. 2015). Obese patients who have trouble overeating can benefit greatly from fexaramine because they will feel less hungry and the body will burn calories fast with diet and exercise combined.

I agree that fexaramine may be safer in humans because it doesn’t make it to the bloodstream like other FXR targeting drugs. Administered under a physician’s guidance, this drug would work in combination with diet and lifestyle changes, much like weight loss surgeries or other obesity treatments.

Leeman Taylor
Senior Criminal Justice Major at Florida A&M University
Real Estate Investor & Internet Marketer

Source: Evans, R. et al. “Imaginary Meal” tricks the body into losing weight” 5 January 2015 Salk Institute

Prevent Weight Gain With Inulin Propionate Ingredient

Researchers at Imperial College and the University of Glasgow discovered that this newly-developed ingredient is effective at preventing weight gain and fat loss in obese individuals. This ingredient contains propionate, which stimulates the gut to release hormones that act on the brain to stop hunger (Wong 2014). Now, individuals who are struggling to lose weight can take advantage of this new ingredient by feeling fuller longer and reducing calories.

Prevent Weight Gain - Fiber

Prevent weight gain with inulin-propionate ingredient, a dietary fiber. ClipArt photo

Propionate is naturally produced when dietary fiber is fermented by microbes in the belly, but the new ingredient, called inulin-propionate Este (IPE), provides much bigger quantities of propionate than individuals can consume with a normal diet (Wong 2014). With these larger amounts of produced propionate, people can reduce hunger because this ingredient acts as an appetite suppressant to make you feel fuller.

To begin with, twenty individuals were given either inulin or IPE, a dietary fiber, and were allowed to eat as much as they wanted from a buffet. How does that sound, being able to eat all you can eat? The volunteers who were given IPE ate 14% less on average, and had higher concentrations of appetite-reducing hormones in their blood (Wong 2014). This means that if you were to take a dose of IPE and eat at a buffet, your appetite or the amount of food you eat can be reduced by 14 percent. This is a great ingredient that can help you feel fuller longer and lose weight by staying away from the buffet line.

Next, sixty overweight individuals participated in a 24-week study in which half were issued IPE as a powder to add to their food and the other half given inulin. One out of 25 participants issued IPE who finished the study gained more than 3 percent of their body weight, compared to 6 out of 24 given inulin (Wong 2014). Surprisingly, none of the IPE group members gained more than 5% of their body weight, compared with 4 in the inulin group. Also, the IPE group had less fat in their abdomens and livers compared with the inulin group after 24 weeks.

 Lose Weight With Dietary Fibers

Feel fuller with inulin-propionate that acts an appetite suppressant to help you burn calories. ClipArt photo

Professor Gary Frost, who led the study at the Department of Medicine at Imperial College London, said “Molecules like propionate stimulate the release of gut hormones that control appetite, but you must eat huge quantities of fiber to accomplish a strong effect.” Frost says that this small, proof-of-principle study demonstrates encouraging signs that supplementing one’s diet with the ingredient they’ve developed prevents weight gain in overweight individuals (Wong 2014). “You need to eat it regularly to have an effect. We’re exploring what kinds of foods it could be added to, but something like bread or fruit smoothies might work well” says Frost.

To say the least, this newly-developed ingredient (IPE), can be a real breakthrough for weight loss if combined with daily physical activity. This is new inulin-propionate may be all you need when it comes to an appetite suppressant and an effective tool to burn calories fast for weight loss. If you are new to losing weight you should consult your doctor or physician before making any unusual physical or diet changes. My goal is to help all men and women lose weight and improve their health so hopefully this new inulin-propionate (IPE) ingredient developed by scientists is really effective in reducing your hunger and preventing weight gain.

Leeman Taylor
Senior Criminal Justice Major at Florida A&M University
Real Estate Investor and Internet Marketer

Source: Wong, S. “Scientists create food ingredient that will make you feel fuller” 10 December 2014 Imperial College London